LAVA Therapeutics Research Pipeline



Our lead program, LAVA-051, is a Gammabody™ that targets CD1d-expressing tumors, including multiple myeloma, chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML). We have achieved preclinical proof-of-concept with LAVA-051 by demonstrating efficacy and safety in a variety of preclinical models. LAVA-051 uniquely activates both Vγ9Vδ2 T cells as well as invariant natural killer T (iNKT) cells, which represent another conserved immune effector cell population, in a target dependent manner.

Enrollment is underway in our open-label, multi-center, Phase 1/2a clinical trial of LAVA-051 for the treatment of relapsed and/or refractory CLL, MM and AML. The trial is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary antitumor activity of LAVA-051. Click here to learn more about the trial


LAVA-1207 is a Gammabody™ that targets the prostate specific membrane antigen (PSMA) and has also demonstrated preclinical proof-of-concept by demonstrating efficacy and safety in a variety of preclinical models. We are initiating a Phase 1/2a trial in metastatic castration-resistant prostate cancer.

Early-Stage Pipeline

In addition to our two named lead programs, we are advancing a portfolio of early-stage programs.


Janssen Collaboration

In May 2020, we entered into a research and license agreement with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson, for the discovery and development of novel bispecific antibodies to gamma-delta T cells for the treatment of cancer. We received an upfront payment, and are eligible to receive potential development and commercial milestone payments and future tiered royalties.